Excellence in Research Award
About the Award
Each year the ASGCT Abstract Review Committee selects 15 top abstracts submitted by students and fellows to receive Excellence in Research Awards. Recipients of the Excellence in Research Awards are announced during the George Stamatoyannopoulos Memorial Lecture at the ASGCT Annual Meeting and receive a monetary award of $500 along with a plaque.
Criteria and Selection
Any ASGCT member or associate member who submits an abstract to the Annual Meeting is eligible to receive the award.
Recipients
2023
Martina Fiumara
Uncovering Upsides and Pitfalls of Base and Prime Editing in Hematopoietic Stem Cells
Alan Rosales
Evolving Nephrotropic AAV Variants Using Ex Vivo NHP Kidney Perfusion and Human Kidney Organoids
William Feist
Establishing Multilayered Genetic Resistance to HIV-1 By Engineering Hematopoietic Stem and Progenitor Cells for B Cell Specific Secretion of Therapeutic Antibodies
Cesare Canepari
Improving The Efficiency Of In Vivo Lentiviral Gene Transfer To Hepatocytes, By Targeting Anti-Viral Pathways, And Application To Familial Hypercholesterolemia
Chun Huang
Genome editing B cells to express custom Heavy chain antibodies with modified antigen specificity and Fc function
Royce Ma
CD5 CAR T-cells promote selection of fratricide-resistant circulating T-cells thus avoiding global T-cell aplasia
Timothy Smith
Newly engineered IgM and IgG cleaving enzymes for AAV gene therapy
Geoffrey Rogers, PhD
Engineered Human B cells Respond to Antigen-Specific Immunization in a Tonsil Organoid Model
Ai Vu Hong
An Integrin-targeting AAV developed by a novel computational rational design methodology presents an improved targeting to the skeletal muscle and reduced tropism to the liver
Gabriele Casirati
Epitope edited hematopoietic stem cells allow immune-based in vivo selection of genome-engineered cells
Junping Zhang, PhD
A new cceAAV vector without a mutant ITR is efficient for reducing subgenome generation
Nadja Meumann
In vivo targeting of HSCs by capsid-engineered AAV vectors
Cassie Turnage
Subacute Liver Injury In Two Young Infants Following Gene Replacement Therapy For Spinal Muscular Atrophy
Rrita Daci
Development of adeno-associated virus (AAV) vectors for intratumoral gene replacement therapy in a novel mouse model of neurofibromatosis type 1 (NF1)
William Nyberg
An Evolved AAV Variant Enables Efficient Genetic Engineering of Murine T Cells and the Modeling of CAR-T Cells in Immunocompetent Tumor Models
2022
Panagiotis Antoniou, PhD
Base Editing of a γ-globin cis-regulatory Element in Human Hematopoietic Stem Cells for Reactivation of Therapeutic Fetal Hemoglobin
Jacob Aurelien, PhD
The Choice of Template Delivery Mitigates the Genotoxic Risk and Adverse Impact of Editing in Human Hematopoietic Stem Cells
Benjamin Arnson
Genome Editing in a Canine Model for Glycogen Storage Disease Type Ia
Tania Baccega, PhD
A Novel Polyfunctional Editing Strategy for Adoptive T Cell Immunotherapy of Cancer
Wassamon Boonying, PhD
Astrocyte-Restricted Gene Silencing Improves the Safety of AAV9-Mediated Gene Therapy for Alexander Disease
Martino Alfredo Cappelluti, PhD
Durable Silencing of Pcsk9 by in vivo Hit-and-run Epigenome Editing
Ting-Yen Chao
Ministring DNA: A Durable and Safe Nonviral Delivery Platform
Amanda Sales Conniff, PhD
DNA Sensor Palmitoylation in Mouse Skeletal Muscle Following DNA Electroporation
Anastasia Conti, PhD
Cellular Senescence and Inflammatory Programs are Unintended Consequences of CRISPR-Cas9 Gene Editing in Hematopoietic Stem and Progenitors Cells
Siddhant Gupte
Development of an AAV-based Gene Therapy for the Ocular Phenotype of Friedreich’s Ataxia
Dalia Haydar, PhD
CD28-based B7-H3 CAR T Cells Have Superior Anti-glioma Efficacy in an Immune Competent Glioma Model While Suppressive Macrophages at Tumor Edges are Associated
Nayan Jain
Disruption of H3K9me3-mediated Gene Silencing Augments CAR T Cell Functional Persistence
Chang Li, PhD
Correction of the Sickle Cell Mutation by In Vivo HSC Prime Editing in a Mouse Model
Feiyan Mo
Engineering T Cells To Prevent Acute Graft-Versus-Host Disease And Leukemia Relapse Following Allogeneic Stem Cell Transplantation
Annita Montepeloso, PhD
Targeting CX3CR1 Gene to Improve Microglia Reconstitution and Transgene Delivery into the CNS Upon Hematopoietic Stem and Progenitor Cell Transplant
Samantha Powers, PhD
A Novel Gene Therapy for Rett Syndrome through Reactivation of the Silent X Chromosome
Huiya Yang
Safe And Efficacious Rescue Of GM3 Synthase Deficiency Mice By Spatially Regulated Gene Delivery
Chi-Yuan Zhang, PhD
A Novel DNA Oligo-based Repair Strategy for the Functional Correction of Shwachman-Diamond Syndrome
2021
Sangya Agarwal
Investigating the Therapeutic Efficacy of Disruption of Cell Intrinsic Checkpoint Regulator CTLA-4 in Chimeric Antigen Receptor T Cells
Antonio Carusillo
Modulation of DNA Repair Pathways by HDR-CRISPR Promotes Seamless Genome Editing in Primary Human Hematopoietic Cells
Yue Du
Vectored Immunoprophylaxis for COVID-19 (COVIP)
Samuele Ferrari
Triggering P53 Activation and Trapping of Transcriptionally Active Recombinant AAV Sequences Are Inadvertent Consequences of HSC Genome Editing
Nayan Jain
CAR Design and Expression Determine Hyper-Proliferative States in TET2 Deficient T Cells
Francesco Manfredi
Exhausted, Tumor-Specific T Cells Can Be Exploited to Generate a Library of T-Cell Receptors for Adoptive T Cell Therapy in Blood Malignancies
Megan Manson
Optimization of Transcutaneous Ultrasound Mediated Gene Delivery into Large Animals
Katharina Meijboom
CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in C9ORF72 Rescues Major Disease Mechanisms
Helena Meyer-Berg
Generation of a Human 3D Lung Model for Therapeutic Gene Editing in Surfactant Protein B Deficiency
Alessio Nahmad
In-Vivo Engineered B Cells Retain Memory and Secrete High Titers of Anti-HIV Antibodies in Mice
Eleni Panagioti
Immunostimulatory Bacterial Antigen-Armed Oncolytic Measles Virotherapy Significantly Increases the Potency of Anti-PD1 Checkpoint Therapy
Sandhya Sharma
Memory Enriched Epstein-Barr Virus {EBV} Specific T-Cells with Broader Target Antigen Repertoire for the Treatment of EBV+ Malignancies
Toloo Taghian
Real-Time MR Tracking of AAV Gene Therapy with Enzyme-Activated MR Probes
Maria Vitale
An Oncolytic Adenoviral Vector Expressing an Anti-PD-L1 scFv Reduces Tumor Growth in a Melanoma Mouse Model
Jesse Weber
Capturing and Characterizing Single Cell Allelic Heterogeneity of CRISPR-Cas9 Gene Editing In Vivo