Solving the First AAV Capsid Structure: A Conversation with Michael S. Chapman, PhD

Widler Casy, PhD - November 14, 2023

Dr. Chapman led the team that solved the very first structure of AAV capsid 20 years ago. Listen to his fondest memories of this remarkable achievement.

More than 20 years ago, ASGCT Member Michael S. Chapman, PhD, led the team of researchers who, for the very first time, presented the atomic structure of adeno-associated virus (AAV-2) to 3-Å resolution.

In this interview with ASGCT Member Widler Casy, PhD, Dr. Chapman talks about the challenges he encountered in the eight years of work before the paper was published, where the field is now in comparison to back then, his career advice for scientists, and much more.

Dr. Casy is Scientist III at Solid Biosciences, Inc. and a member of ASGCT's Communications Committee.